|
|
|
|
PATIENT TESTING |
Use two different monoclonal Anti-D antisera
Should not detect DVI; if in doubt (eg discrepancies)
classify as RhD neg
|
Recommended Antisera Combinations
No 1 Z031U Anti-D alpha
No 2 Z036U Anti-D beta
OR
No 2 Z041U Anti-D blend |
Cell Line
LDM1 (IgM)
LDM3 (IgM)
LDM3/ESD1
(IgM/IgG) |
Epitope Specificity*
6.5
6.5
6.5/9.1 |
Comments
Detects DVI by IAGT only
IAGT should not normally
be performed on patients |
|
NEONATAL TESTING |
Use two different monoclonal Anti-D antisera |
Recommended Antisera Combinations
No 1 Z031U Anti-D alpha
No 2 Z041U Anti-D blend
OR
No 1 Z036U Anti-D beta
No 2 Z039U Anti-D delta
|
Cell Line
LDM1 (IgM)
LDM3/ESD1
LDM3 (IgM)
LDM1/ESD1-M
(IgM/IgM) |
Epitope Specificity*
6.5
6.5/9.1
6.5
6.5/9.1
|
Comments
Will detect all RhD variants
including DVI by IAGT only
Will detect most RhD variants
including DVI by direct
agglutination
|
|
DONOR TESTING |
Use two different monoclonal Anti-D antisera
At least one should detect DVI. If in doubt (eg discrepancies) classify as RhD Pos
|
Recommended Antisera Combinations
No 1 Z036U Anti-D beta
No 2 Z039U Anti-D delta |
Cell Line
LDM3 (IgM)
LDM1/ESD1-M
(IgM/IgM)
|
Epitope Specificity*
6.5
6.5/9.1
|
Comments
Will detect most RhD variants
including DVI by direct
agglutination |
Notes
1 The detection rate for weak D and RhD variants depends on the
technique used. Slide techniques are not recommended for detection of weak D
samples.
2 As the cell lines LDM1 and LDM3 have identical RhD
epitope specificity, grouping discrepancies will be minimised by using Z031U and
Z036U as a matched pair.
Cautionary statements:
Source material from which some of these products are derived was found
non reactive for HbsAg, Anti HIV 1/2 and ANTI HCV. No known test methods
can offer assurance that products derived from human blood will not transmit
infectious disease. Appropriate care should be taken in the use and disposal of
these products.
This product has components (dropper bulbs) containing dry natural
rubber.
Prior to use, always consult the instructions for use which are
enclosed with the product or available on our website.